@import url('https://fonts.googleapis.com/css2?family=DM+Sans:wght@400;450;500;550;600;650;700&family=Manrope:wght@400;500;600;650;700;750;800&display=swap');
:root{--ink:#16213c;--muted:#58647a;--blue:#2d50e8;--line:#e2e7ef;--pale:#f3f6fa;--radius:18px}
*{box-sizing:border-box}
html{scroll-behavior:smooth;scroll-padding-top:32px}
body{margin:0;color:var(--ink);background:#fff;font-family:'DM Sans',Arial,sans-serif;font-size:1rem;line-height:1.7;-webkit-font-smoothing:antialiased}
::selection{background:#dae3ff;color:#16213c}
a{color:inherit;text-decoration:none}
a:focus-visible,summary:focus-visible{outline:3px solid var(--blue);outline-offset:5px;border-radius:4px}
summary{-webkit-tap-highlight-color:transparent}
.wrap{width:min(1240px,calc(100% - 96px));margin-inline:auto}
.header{display:flex;align-items:center;justify-content:space-between;min-height:96px;gap:28px;border-bottom:1px solid var(--line)}
.brand{display:inline-flex;align-items:center;gap:9px;font-family:Manrope,Arial,sans-serif;font-size:1.4375rem;font-weight:800;letter-spacing:-1px;white-space:nowrap;line-height:1.3}
.brand-symbol{display:grid;place-items:center;width:34px;height:36px;flex:none;background:var(--blue);color:#fff;border-radius:10px;font-size:1.5625rem;letter-spacing:-2px;padding-right:3px}
.brand-atlas{font-weight:450;margin-left:-4px}
.header nav{display:flex;flex-wrap:wrap;gap:10px 30px;font-size:.875rem;font-weight:550}
.header nav a{padding-block:12px}
.header nav a:hover{color:var(--blue)}
.header-note{font-size:.8125rem;color:var(--muted)}
.hero{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);align-items:center;gap:44px;min-height:590px;padding-block:58px 62px}
.eyebrow{font-size:.75rem;font-weight:650;letter-spacing:1.5px;margin:0 0 24px;color:var(--blue)}
h1,h2,h3,h4{font-family:Manrope,Arial,sans-serif;line-height:1.17;overflow-wrap:break-word}
h1{font-size:clamp(2.875rem,4.7vw,4.25rem);font-weight:600;letter-spacing:-.048em;margin:0 0 27px}
h1 span{color:var(--blue)}
.hero-text{font-size:1.125rem;line-height:1.8;max-width:490px;color:var(--muted);margin:0 0 28px}
.button{display:inline-flex;align-items:center;gap:37px;background:var(--blue);color:#fff;padding:14px 22px;border-radius:7px;font-size:.9375rem;font-weight:550;transition:background .2s}
.button span{font-size:1.3125rem;line-height:1}
.button:hover{background:#1f3dc2}
.edition{font-size:.75rem;color:var(--muted);margin:23px 0 0}
.hero-art{margin:0;background:#edf5fe;border-radius:var(--radius);position:relative;overflow:hidden;aspect-ratio:1.17;min-width:0;align-self:stretch;max-height:470px}
.hero-art img{display:block;width:100%;height:100%;object-fit:cover;object-position:58% center}
.hero-art figcaption{position:absolute;inset:auto 23px 19px;display:flex;flex-wrap:wrap;justify-content:space-between;gap:8px 14px;font-size:.75rem;line-height:1.5;color:#3b5273}
.hero-art figcaption span:first-child{font-size:.75rem;letter-spacing:1px;align-self:center;font-weight:600}
.primer{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:34px;border-block:1px solid var(--line);padding-block:27px}
.primer>div{display:flex;gap:17px;min-width:0}
.primer-number{font-size:.75rem;color:var(--blue);font-weight:650;padding-top:4px}
.primer p{font-size:.875rem;line-height:1.7;color:var(--muted);margin:0}
.primer strong{color:var(--ink);font-weight:650}
.section{padding-block:76px;scroll-margin-top:15px}
.section-top{display:flex;align-items:flex-end;justify-content:space-between;gap:52px;margin-bottom:38px}
.section-top>div{min-width:0}
.section-top .eyebrow{margin-bottom:13px}
h2{font-size:2.25rem;letter-spacing:-.04em;font-weight:600;margin:0 0 20px}
.section-top h2{margin:0}
.section-top>p{max-width:390px;margin:0;color:var(--muted);font-size:1rem;line-height:1.7}
.featured-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:22px;align-items:start}
.featured{padding:27px 28px 0;background:#f5f7fb;border:1px solid #e6ebf3;border-radius:var(--radius);min-width:0}
.card-top{display:flex;align-items:center;justify-content:space-between;gap:10px}
.card-number{font-size:.75rem;color:#657189}
.tag{display:inline-flex;align-items:center;padding:5px 9px;font-size:.875rem;border-radius:5px;line-height:1.5;font-weight:500}
.approved{color:#1b6555;background:#e3f1eb}
.clinical{color:#76530d;background:#fff0c8}
.early{color:#5c557b;background:#efedf6}
.molecule-code{font-size:.75rem;letter-spacing:1px;color:#456095;margin:36px 0 12px;font-weight:550;line-height:1.6;min-height:20px}
.featured h3{font-size:1.8125rem;letter-spacing:-.034em;font-weight:650;margin:0 0 17px}
.card-intro{color:var(--muted);margin:0 0 24px;min-height:109px;font-size:1rem;line-height:1.7}
.card-meta{display:flex;gap:8px;flex-wrap:wrap;padding-bottom:27px;font-size:.75rem;color:#4f5e77}
.card-meta span{border:1px solid #dce3ef;border-radius:4px;padding:3px 8px}
summary{cursor:pointer;list-style:none}
summary::-webkit-details-marker{display:none}
summary::marker{content:''}
.card-details>summary{padding-block:18px;border-top:1px solid #dce3ef;display:flex;justify-content:space-between;align-items:center;gap:20px;font-size:.875rem;font-weight:600;color:var(--blue)}
.toggle{height:16px;width:16px;position:relative;flex-shrink:0;display:block;color:var(--blue)}
.toggle:before,.toggle:after{content:'';position:absolute;background:currentColor;inset:7px 1px;height:1.5px}
.toggle:after{transform:rotate(90deg);transition:transform .2s}
details[open]>summary .toggle:after{transform:rotate(0)}
.card-detail-body{border-top:1px solid #dce3ef;padding-block:3px 25px}
h4{font-size:1rem;line-height:1.5;margin:22px 0 6px;font-weight:650}
.card-detail-body p{font-size:1rem;line-height:1.75;color:var(--muted);margin:0 0 18px}
.source-link{display:flex;gap:10px;justify-content:space-between;align-items:flex-start;color:var(--blue);font-size:.875rem;line-height:1.6;padding:9px 0;font-weight:500}
.source-link span{flex:none}
.source-link:hover{text-decoration:underline;text-underline-offset:3px}
.section-note{font-size:.75rem;line-height:1.7;color:var(--muted);margin:20px 0 0}
.directory-section{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,2fr);gap:70px;border-top:1px solid var(--line);padding-block:70px 86px}
.directory-intro .eyebrow{margin-bottom:17px}
.directory-intro h2{font-size:2rem;letter-spacing:-.038em;line-height:1.25}
.directory-intro>p:not(.eyebrow){font-size:1rem;color:var(--muted);line-height:1.75;margin:0}
.directory-note{border-left:2px solid #cad4fa;padding-left:17px;margin-top:33px}
.directory-note>span{font-size:.75rem;letter-spacing:1.1px;color:var(--blue);font-weight:600}
.directory-note p{font-size:.875rem;line-height:1.7;color:var(--muted);margin:7px 0 0}
.profile{border-bottom:1px solid var(--line);scroll-margin-top:25px}
.profile:first-child{border-top:1px solid var(--line)}
.profile>summary{display:grid;grid-template-columns:22px minmax(0,1fr) auto 18px;align-items:center;gap:17px;padding-block:24px}
.profile>summary:hover .profile-name>span{color:var(--blue)}
.profile-index{font-size:.75rem;color:#68758b;align-self:start;padding-top:3px}
.profile-name{display:flex;flex-direction:column;gap:4px;min-width:0}
.profile-name>span{font-family:Manrope,Arial,sans-serif;font-size:1.25rem;line-height:1.5;font-weight:650;letter-spacing:-.025em;transition:color .2s;overflow-wrap:anywhere}
.profile-name small{font-size:.875rem;font-weight:400;color:var(--muted);line-height:1.6}
.profile-body{padding:0 0 25px 39px;font-size:1rem;color:var(--muted)}
.profile-body p{margin:0 0 18px;line-height:1.8}
.profile-body strong{color:var(--ink);font-weight:600}
.profile-body .source-link{justify-content:flex-start;gap:15px;padding:7px 0}
.profile[open]>summary{padding-bottom:20px}
.evidence{background:#142340;color:#fff;padding-block:70px 30px;scroll-margin-top:0}
.evidence .eyebrow{color:#a8bdff;margin-bottom:20px}
.evidence-heading{display:flex;align-items:flex-end;justify-content:space-between;gap:65px;margin-bottom:45px}
.evidence-heading>div{min-width:0}
.evidence-heading h2{font-size:2.4375rem;line-height:1.25;letter-spacing:-.036em;margin:0}
.evidence-heading>p{max-width:350px;font-size:1rem;color:#c5cfdf;line-height:1.8;margin:0}
.evidence-heading em{color:#fff;font-style:normal}
.evidence-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:42px}
.evidence-grid article{border-top:1px solid #475570;padding-top:26px}
.stage{font-size:.75rem;letter-spacing:1.3px;color:#a8bdff}
.evidence-grid h3{font-size:1.375rem;font-weight:550;letter-spacing:-.023em;margin:18px 0 14px}
.evidence-grid p{font-size:1rem;color:#c5cfdf;line-height:1.8;margin:0 0 26px}
.evidence-label{display:inline-block;font-size:.875rem;border:1px solid #4b5a77;padding:5px 10px;border-radius:4px;color:#e2e9f8}
.evidence-footnote{font-size:.8125rem;color:#acbbd2;line-height:1.8;border-top:1px solid #354763;margin:38px 0 0;padding-top:24px}
.sources{padding-top:76px;padding-bottom:45px}
.sources .section-top>p{max-width:340px}
.source-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:42px}
.source-group{border-top:1px solid var(--line);padding-top:24px;min-width:0}
.source-type{color:var(--muted);font-size:.75rem;letter-spacing:1.3px;font-weight:600}
.source-group h3{font-size:1.25rem;letter-spacing:-.025em;font-weight:650;margin:12px 0 19px}
.source-group>a{display:flex;align-items:flex-start;justify-content:space-between;gap:10px;font-size:.875rem;line-height:1.7;padding-block:9px;color:#405274}
.source-group>a span{color:var(--blue);flex:none}
.source-group>a:hover{color:var(--blue);text-decoration:underline;text-underline-offset:4px}
.source-group>p{font-size:.875rem;line-height:1.8;color:var(--muted);margin:19px 0 0}
.editorial-note{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:42px;border-top:1px solid var(--line);margin-top:37px;padding-top:27px;color:var(--muted)}
.editorial-note p{font-size:.8125rem;line-height:1.8;margin:0}
.editorial-note strong{font-weight:600;color:#384860}
.footer{border-top:1px solid var(--line);padding-block:33px 28px}
.footer-top{display:flex;align-items:center;justify-content:space-between;gap:25px;margin-bottom:23px}
.footer .brand{font-size:1.3125rem}
.footer .brand-symbol{width:29px;height:31px;font-size:1.375rem;border-radius:8px}
.back-top{font-size:.875rem;color:var(--muted);padding:10px 0;white-space:nowrap}
.back-top span{color:var(--blue);margin-left:13px}
.back-top:hover{color:var(--blue)}
.footer-bottom{display:flex;justify-content:space-between;gap:45px;font-size:.75rem;color:var(--muted)}
.footer-bottom p{max-width:740px;line-height:1.8;margin:0}
.footer-bottom>span{white-space:nowrap}
.skip{position:absolute;left:16px;top:-100px;padding:8px 15px;background:white;z-index:99}
.skip:focus{top:12px}
@media(min-width:1500px){.hero{min-height:620px}.hero-art{max-height:490px}}
@media(max-width:1150px){.wrap{width:calc(100% - 64px)}.header-note{display:none}.hero{gap:30px;min-height:550px}.hero-art{max-height:440px}.featured{padding-inline:22px}.card-intro{min-height:136px}.card-number{display:none}.directory-section{gap:38px;grid-template-columns:minmax(0,1fr) minmax(0,2.1fr)}.profile>summary{gap:12px}.evidence-heading h2{font-size:2.1875rem}.source-grid{gap:28px}.section-top{gap:30px}.sources .section-top>p{max-width:300px}.section-top h2{font-size:2rem}}
@media(max-width:980px){.header{min-height:86px}.hero{min-height:auto;padding-block:48px}.hero-art{aspect-ratio:auto;min-height:390px}.hero-art figcaption span:first-child{display:none}.hero-art figcaption{justify-content:flex-end}.hero-text{font-size:1rem}h1{font-size:2.9375rem;letter-spacing:-.053em}.primer{gap:20px}.primer>div{gap:10px}.section-top{display:block}.section-top>p,.sources .section-top>p{max-width:580px;margin-top:18px}.featured-grid{grid-template-columns:1fr;gap:18px}.featured{padding-inline:28px}.card-top .card-number{display:block}.card-intro{min-height:0}.card-meta{padding-bottom:23px}.molecule-code{margin-top:28px}.directory-section{grid-template-columns:1fr;gap:30px}.directory-intro{max-width:700px}.directory-intro h2 br{display:none}.directory-note{margin-top:20px;max-width:650px}.profile>summary{grid-template-columns:26px minmax(0,1fr) auto 20px;gap:17px}.evidence-heading{gap:30px}.evidence-heading h2{font-size:1.9375rem}.evidence-heading>p{max-width:290px}.evidence-grid{gap:25px}.evidence-grid h3{font-size:1.25rem}.source-grid{gap:23px}.source-group h3{font-size:1.125rem}.editorial-note{gap:28px}}
@media(max-width:720px){.wrap{width:calc(100% - 40px)}.header{min-height:80px;flex-wrap:wrap;gap:0;padding:19px 0 12px}.brand{font-size:1.375rem}.header nav{width:100%;justify-content:space-between;gap:6px 12px;font-size:.875rem;margin-top:11px}.header nav a{padding-block:9px}.hero{grid-template-columns:1fr;padding-block:36px;gap:30px}.hero-copy .eyebrow{margin-bottom:20px}h1{font-size:3.375rem;letter-spacing:-.055em;line-height:1.12;margin-bottom:23px}.hero-text{font-size:1.0625rem;line-height:1.8;max-width:none;margin-bottom:24px}.hero-art{aspect-ratio:1.5;min-height:0;max-height:none}.hero-art figcaption{inset:auto 15px 13px}.hero-art img{object-position:center}.edition{margin-top:20px}.button{padding:14px 21px}.primer{grid-template-columns:1fr;gap:20px;padding-block:27px}.primer>div{gap:16px}.primer-number{min-width:19px}.section{padding-block:48px}.section-top{margin-bottom:29px}.section-top h2,h2{font-size:1.9375rem;letter-spacing:-.042em;line-height:1.25}.eyebrow{letter-spacing:1.2px}.featured{padding:26px 26px 0}.featured h3{font-size:1.875rem;margin-bottom:17px}.card-intro{margin-bottom:22px}.card-details>summary{font-size:.9375rem;padding-block:19px}.directory-section{padding-block:45px 55px;gap:30px}.directory-intro h2{font-size:1.875rem}.profile>summary{grid-template-columns:22px minmax(0,1fr) 18px;gap:6px 12px;padding-block:21px}.profile-index{grid-column:1;grid-row:1}.profile-name{grid-column:2;grid-row:1}.profile>summary .tag{grid-column:2;grid-row:2;justify-self:start;margin-top:5px}.profile>summary .toggle{grid-column:3;grid-row:1 / span 2;align-self:center}.profile-body{padding:0 0 22px 34px}.profile-body p{line-height:1.8;margin-bottom:17px}.profile-body .source-link{line-height:1.75}.evidence{padding-block:48px 28px}.evidence-heading{display:block;margin-bottom:32px}.evidence-heading h2{font-size:1.9375rem;letter-spacing:-.039em}.evidence-heading>p{max-width:none;margin-top:22px}.evidence-grid{grid-template-columns:1fr;gap:29px}.evidence-grid article{padding-top:22px}.evidence-grid h3{font-size:1.5rem;margin-top:14px}.evidence-grid p{margin-bottom:19px}.evidence-footnote{margin-top:30px;padding-top:22px}.sources .section-top h2{max-width:350px}.source-grid{grid-template-columns:1fr;gap:28px}.source-group{padding-top:22px}.source-group h3{font-size:1.375rem;margin-top:10px}.source-group>a{font-size:.9375rem;padding-block:11px}.editorial-note{grid-template-columns:1fr;gap:18px;margin-top:30px;padding-top:24px}.footer{padding-block:28px}.footer-top{gap:15px;flex-wrap:wrap}.footer .brand{font-size:1.1875rem}.footer-bottom{display:block}.footer-bottom>p{font-size:.8125rem}.footer-bottom>span{display:block;margin-top:18px}}
@media(max-width:380px){h1{font-size:2.875rem;letter-spacing:-.056em}.hero-copy .eyebrow{letter-spacing:.5px}.header nav{gap:6px 8px}.featured{padding-inline:21px}.profile-name>span{font-size:1.125rem}.profile-body{padding-left:0}.footer .brand{font-size:1.125rem}.back-top span{margin-left:5px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*:before,*:after{transition:none!important}}